Interleukin-10 Regulates Hepcidin in Plasmodium falciparum Malaria
نویسندگان
چکیده
منابع مشابه
Interleukin-10 Regulates Hepcidin in Plasmodium falciparum Malaria
BACKGROUND Acute malarial anemia remains a major public health problem. Hepcidin, the major hormone controlling the availability of iron, is raised during acute and asymptomatic parasitemia. Understanding the role and mechanism of raised hepcidin and so reduced iron availability during infection is critical to establish evidence-based guidelines for management of malaria anemia. Our recent clin...
متن کاملInterleukin-8 and Plasmodium falciparum malaria in Thailand.
Jon S. Friedland’, May H02,3, Daniel G. Remick”, llyl;;i Bunnagz, Nicholas J. White*,5 and George E. * 1 ‘Division of Communicable Diseases, St George’s Hospital Medical School, London, UK; *Hospital for Tropical Diseases and Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; 3Department of Microbiology and Infectious Diseases, University of Calgay, Calgay, Canada; 4Department...
متن کاملLow interleukin-12 activity in severe Plasmodium falciparum malaria.
We compared interleukin-12 (IL-12) and other cytokine activities during and after an acute clinical episode in a matched-pair case-control study of young African children who presented with either mild or severe Plasmodium falciparum malaria. The acute-phase, pretreatment plasma IL-12 and alpha interferon (IFN-alpha) levels, as well as the acute-phase mitogen-stimulated whole-blood production c...
متن کاملThrombocytopenia in plasmodium falciparum malaria.
BACKGROUND Malaria is usually associated with reduced blood cell counts & mild to moderate thrombocytopenia is a common association of malaria. The cause of thrombocytopenia is poorly understood, but the immune-mediated lysis, sequestration in the spleen and dyspoietic processes in the marrow with diminished platelet production have all been postulated. This study was conducted to evaluate thro...
متن کاملRelationship of hepcidin with parasitemia and anemia among patients with uncomplicated Plasmodium falciparum malaria in Ghana.
The pathogenesis of malarial anemia is incompletely understood. Hepcidin, a recently discovered peptide hormone, is a major regulator of iron metabolism and is thought to play a central role in the anemia of chronic inflammation. The specific aim of the study was to characterize the association between urinary hepcidin, hemoglobin, and parasitemia in 199 patients presenting for evaluation of Pl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0088408